abstract：:The metabotropic glutamate receptor 2 (mGlu2) plays an important role in the presynaptic control of glutamate release and several mGlu2 positive allosteric modulators (PAMs) have been under assessment for their potential as antipsychotics. The binding mode of mGlu2 PAMs is better characterized in functional terms whil...

journal_title：Neuropharmacology

authors： Lundström L,Bissantz C,Beck J,Dellenbach M,Woltering TJ,Wichmann J,Gatti S

更新日期：2017-03-15 00:00:00

abstract：:Slow excitatory postsynaptic currents (EPSCs) mediated by metabotropic glutamate receptors (mGlu receptors) have been reported in several neuronal subtypes, but their presence in hippocampal pyramidal neurons remains elusive. Here we find that in CA1 pyramidal neurons a slow EPSC is induced by repetitive stimulation w...

journal_title：Neuropharmacology

authors： Sheng N,Yang J,Silm K,Edwards RH,Nicoll RA

更新日期：2017-03-15 00:00:00

abstract：:Metabotropic glutamate receptor subtype 5 (mGluR5), encoded by the GRM5 gene, represents a compelling novel drug target for the treatment of schizophrenia. mGluR5 is a postsynaptic G-protein coupled glutamate receptor strongly linked with several critical cellular processes that are reported to be disrupted in schizop...

journal_title：Neuropharmacology

authors： Matosin N,Fernandez-Enright F,Lum JS,Newell KA

更新日期：2017-03-15 00:00:00

abstract：:Inflammation plays a central role in the processes associated with neurodegeneration. The inflammatory response is mediated by activated microglia that release inflammatory mediators to the neuronal environment. Microglia-derived lysosomal cathepsins, including cathepsin X, are increasingly recognized as important med...

journal_title：Neuropharmacology

authors： Pišlar A,Božić B,Zidar N,Kos J

更新日期：2017-03-01 00:00:00

abstract：:The functional expression of H4 receptors (H4R) within neurons of the central nervous system has been recently reported, but their role is poorly understood. The present study aims to elucidate the role of neuronal H4R by providing the first description of the behavioural phenotype of H4R-deficient (H4R knockout, H4R-...

journal_title：Neuropharmacology

authors： Sanna MD,Ghelardini C,Thurmond RL,Masini E,Galeotti N

更新日期：2017-03-01 00:00:00

abstract：:The N-methyl-d-aspartate (NMDA) receptor is a key target of ethanol action in the central nervous system. Alcohol inhibition of NMDA receptor function involves small clusters of residues in the third and fourth membrane-associated (M) domains. Previous results from this laboratory have shown that two adjacent position...

journal_title：Neuropharmacology

authors： Ren H,Zhao Y,Wu M,Dwyer DS,Peoples RW

更新日期：2017-03-01 00:00:00

abstract：:The neuroactive steroid (NAS) tetrahydrodeoxycorticosterone (THDOC) increases protein kinase C (PKC) mediated phosphorylation of extrasynaptic GABAA receptor (GABAAR) subunits leading to increased surface expression of α4/β3 subunit-containing extrasynaptic GABAARs, leading to a sustained increase in GABAAR tonic curr...

journal_title：Neuropharmacology

authors： Modgil A,Parakala ML,Ackley MA,Doherty JJ,Moss SJ,Davies PA

更新日期：2017-02-01 00:00:00

abstract：:Spinal metabotropic serotonin receptors encode transient experiences into long-lasting changes in motor behavior (i.e. motor plasticity). While interactions between serotonin receptor subtypes are known to regulate plasticity, the significance of molecular divergence in downstream G protein coupled receptor signaling ...

journal_title：Neuropharmacology

authors： Fields DP,Mitchell GS

更新日期：2017-02-01 00:00:00

abstract：:The cognitive impairments and negative symptoms experienced by schizophrenia patients still await effective treatment. Alpha7 nicotinic acetylcholine receptors (α7 nAChRs) have gain considerable attention in this regard. It has been recently proposed that positive allosteric modulators (PAMs) of α7 nAChRs may represen...

journal_title：Neuropharmacology

authors： Potasiewicz A,Hołuj M,Kos T,Popik P,Arias HR,Nikiforuk A

更新日期：2017-02-01 00:00:00

abstract：:G protein-coupled receptor 35 (GPR35) is an orphan G protein-coupled receptor (GPCR) that can be activated by kynurenic acid at high micromolar concentrations. A previously unappreciated mechanism of action of GPR35 has emerged as a Gαi/o-coupled inhibitor of synaptic transmission, a finding that has significant impli...

journal_title：Neuropharmacology

authors： Mackenzie AE,Milligan G

更新日期：2017-02-01 00:00:00

abstract：BACKGROUND:Bipolar disorder (BD) mania patients exhibit poor cognition and reward-seeking/hypermotivation, negatively impacting a patient's quality of life. Current treatments (e.g., lithium), do not treat such deficits. Treatment development has been limited due to a poor understanding of the neural mechanisms underly...

journal_title：Neuropharmacology

authors： Milienne-Petiot M,Kesby JP,Graves M,van Enkhuizen J,Semenova S,Minassian A,Markou A,Geyer MA,Young JW

更新日期：2017-02-01 00:00:00

abstract：:The risk of Alzheimer's disease (AD) is higher in patients with type 2 diabetes mellitus (T2DM). Previous studies in high-fat diet-induced AD animal models have shown that brain insulin resistance in these animals leads to the accumulation of amyloid beta (Aβ) and the reduction in GSK-3β phosphorylation, which promote...

journal_title：Neuropharmacology

authors： Kang S,Kim CH,Jung H,Kim E,Song HT,Lee JE

更新日期：2017-02-01 00:00:00

abstract：:The United States is in the midst of an opiate epidemic, with abuse of prescription and illegal opioids increasing steadily over the past decade. While it is clear that there is a genetic component to opioid addiction, there is a significant portion of heritability that cannot be explained by genetics alone. The curre...

journal_title：Neuropharmacology

authors： Vassoler FM,Oliver DJ,Wyse C,Blau A,Shtutman M,Turner JR,Byrnes EM

更新日期：2017-02-01 00:00:00

abstract：:Toll-like receptors (TLRs) are the sensors of pathogen-associated molecules that trigger tailored innate immune intracellular signalling responses to initiate innate immune reactions. Data from the experimental autoimmune encephalomyelitis (EAE) model indicates that TLR signalling machinery is a pivotal player in the ...

journal_title：Neuropharmacology

authors： Fitzpatrick JK,Downer EJ

更新日期：2017-02-01 00:00:00

abstract：:Tryptophan (Trp) availability for the kynurenine pathway (KP) across the life span is discussed. Free (non-albumin-bound) plasma Trp is the major determinant of the flux of Trp down the KP. Flux is the major determinant of kynurenine metabolite formation and is more effective than induction of hepatic Trp 2,3-dioxygen...

journal_title：Neuropharmacology

authors： Badawy AA

更新日期：2017-01-01 00:00:00

abstract：:N-methyl-d-aspartate receptors (NMDARs) are profound regulators of glutamate neurotransmission and behavior. To coordinate components of the limbic system, the dorsal and ventral striatum integrate cognitive and emotional information towards the execution of complex behaviors. Striatal outflow is conveyed by medium sp...

journal_title：Neuropharmacology

authors： Joffe ME,Vitter SR,Grueter BA

更新日期：2017-01-01 00:00:00

abstract：:A major mouse model widely adopted in recent years to induce pronounced ethanol intake is the ethanol vapor model known as "CIE" or "Chronic Intermittent Ethanol." One critical question concerning this model is whether the rapid induction of high blood ethanol levels for such short time periods is sufficient to induce...

journal_title：Neuropharmacology

authors： Renteria R,Maier EY,Buske TR,Morrisett RA

更新日期：2017-01-01 00:00:00

abstract：:The kynurenine pathway (KP) of tryptophan metabolism has emerged in recent years as a key regulator of the production of both neuroprotective (e.g. kynurenic and picolinic acid, and the essential cofactor NAD+) and neurotoxic metabolites (e.g. quinolinic acid, 3-hydroxykynurenine). The balance between the production o...

journal_title：Neuropharmacology

authors： Lovelace MD,Varney B,Sundaram G,Lennon MJ,Lim CK,Jacobs K,Guillemin GJ,Brew BJ

更新日期：2017-01-01 00:00:00

abstract：:The kynurenine pathway of tryptophan metabolism has been implicated in brain function, immunoregulation, anti-microbial mechanisms and pregnancy. Some of these actions are due to depletion of tryptophan and others to the formation of biologically active metabolites. This review focuses on the roles of the kynurenine p...

journal_title：Neuropharmacology

authors： Hunt NH,Too LK,Khaw LT,Guo J,Hee L,Mitchell AJ,Grau GE,Ball HJ

更新日期：2017-01-01 00:00:00

abstract：:Suicide is a major global problem, claiming more than 800,000 lives annually. The neurobiological changes that underlie suicidal ideation and behavior are not fully understood. Suicidal patients have been shown to display elevated levels of inflammation both in the central nervous system and the peripheral blood. A gr...

journal_title：Neuropharmacology

authors： Bryleva EY,Brundin L

更新日期：2017-01-01 00:00:00

abstract：:Addiction is associated with changes in synaptic plasticity mediated, in part, by alterations in the trafficking and stabilization of AMPA receptors at synapses within the nucleus accumbens. Exposure to cocaine can lead to protein kinase C-mediated phosphorylation of GluA2 AMPA subunits and this phosphorylation event ...

journal_title：Neuropharmacology

authors： Briand LA,Deutschmann AU,Ellis AS,Fosnocht AQ

更新日期：2016-12-01 00:00:00

abstract：:Caretakers and clinicians alike have long recognized that individuals with autism spectrum disorder (ASD) can have altered sensory processing, which can contribute to its core symptoms. However, the pathobiology of sensory alterations in ASD is poorly understood. Here we examined nocifensive behavior in ASD mouse mode...

journal_title：Neuropharmacology

authors： Wang L,Almeida LE,Nettleton M,Khaibullina A,Albani S,Kamimura S,Nouraie M,Quezado ZM

更新日期：2016-12-01 00:00:00

abstract：:Nerve growth factor (NGF) holds a pivotal role in brain development and maintenance, been also involved in the pathophysiology of neurodegenerative diseases. Here, we provide evidence that a novel C17-spiroepoxy steroid derivative, BNN27, specifically interacts with and activates the TrkA receptor of NGF, inducing pho...

journal_title：Neuropharmacology

authors： Pediaditakis I,Efstathopoulos P,Prousis KC,Zervou M,Arévalo JC,Alexaki VI,Nikoletopoulou V,Karagianni E,Potamitis C,Tavernarakis N,Chavakis T,Margioris AN,Venihaki M,Calogeropoulou T,Charalampopoulos I,Gravanis A

更新日期：2016-12-01 00:00:00

abstract：:We previously reported that elevated pressure induces axonal swelling and facilitates the synthesis of the neurosteroid, allopregnanolone (AlloP), in the ex vivo rat retina. Exogenously applied AlloP attenuates the axonal swelling, suggesting that the neurosteroid plays a neuroprotective role against glaucomatous pres...

journal_title：Neuropharmacology

authors： Ishikawa M,Yoshitomi T,Covey DF,Zorumski CF,Izumi Y

更新日期：2016-12-01 00:00:00

abstract：:Ethanol addiction is a serious public health problem that still needs more effective pharmacological treatment. A key factor in the development and maintenance of this disease is the advent of neuroadaptations in the mesocorticolimbic brain pathway upon chronic ethanol abuse. In general, these neuroadaptations are mal...

journal_title：Neuropharmacology

authors： Morais-Silva G,Alves GC,Marin MT

更新日期：2016-11-01 00:00:00

abstract：:P2Y1 receptors mediate nerve mediated purinergic inhibitory junction potentials (IJP) and relaxations in the gastrointestinal (GI) tract in a wide range of species including rodents and humans. A new P2Y1 antagonist, with a non-nucleotide structure, BPTU, has recently been described using X-ray crystallography as the ...

journal_title：Neuropharmacology

authors： Mañé N,Jiménez-Sábado V,Jiménez M

更新日期：2016-11-01 00:00:00

abstract：:Though amyloid precursor protein (APP) can potentially be cleaved to generate the pathological amyloid β peptide (Aβ), APP itself plays an important role in regulating neuronal activity. APP deficiency causes functional impairment in cholinergic synaptic transmission and cognitive performance. However, the mechanisms ...

journal_title：Neuropharmacology

authors： Cai ZL,Zhang JJ,Chen M,Wang JZ,Xiao P,Yang L,Long C

更新日期：2016-11-01 00:00:00

abstract：:Endogenous interferon beta (IFNβ) is an important cytokine involved in several chronic inflammatory diseases, such as Multiple Sclerosis (MS). In spite of the numerous therapeutic approaches available for MS patients, the administration of recombinant IFNβ continues being one of the first line treatment to these patie...

journal_title：Neuropharmacology

authors： Suardíaz M,Clemente D,Marin-Bañasco C,Orpez T,Hurtado-Guerrero I,Pavía J,Pinto-Medel MJ,De Castro F,Leyva L,Fernández O,Oliver B

更新日期：2016-11-01 00:00:00

abstract：:Cannabinoid CB2 receptors (CB2Rs) are emerging as important therapeutic targets in brain disorders that typically involve neurometabolic alterations. We here addressed the possible role of CB2Rs in the regulation of glucose uptake in the mouse brain. To that aim, we have undertaken 1) measurement of (3)H-deoxyglucose ...

journal_title：Neuropharmacology

authors： Köfalvi A,Lemos C,Martín-Moreno AM,Pinheiro BS,García-García L,Pozo MA,Valério-Fernandes Â,Beleza RO,Agostinho P,Rodrigues RJ,Pasquaré SJ,Cunha RA,de Ceballos ML

更新日期：2016-11-01 00:00:00

abstract：:Recently we reported that fluoxetine (10 mg/kg) improves functional recovery by attenuating blood spinal cord barrier (BSCB) disruption after spinal cord injury (SCI). Here we investigated whether a low-dose of fluoxetine (1 mg/kg) and vitamin C (100 mg/kg), separately not possessing any protective effect, prevents BS...

journal_title：Neuropharmacology

authors： Lee JY,Choi HY,Yune TY

更新日期：2016-10-01 00:00:00

abstract：:The overexpression of Kir3.2, a subunit of the G protein-gated inwardly rectifying K(+) channel, is implicated in some of the neurological phenotypes of Down syndrome (DS). Chemical compounds that block Kir3.2 are expected to improve the symptoms of DS. The purpose of this study is to develop a cell-based screening sy...

journal_title：Neuropharmacology

authors： Kawada H,Inanobe A,Kurachi Y

更新日期：2016-10-01 00:00:00

abstract：:Recent evidence suggests an early involvement of dopaminergic (DA) processes and terminals in Parkinson's disease (PD). The arborization of neurons depends on the actin cytoskeleton, which in turn is regulated by small GTPases of the Rho family, encompassing Rho, Rac and Cdc42 subfamilies. Indeed, some reports point t...

journal_title：Neuropharmacology

authors： Musilli M,Ciotti MT,Pieri M,Martino A,Borrelli S,Dinallo V,Diana G

更新日期：2016-10-01 00:00:00

abstract：:Dopamine (DA) neurotransmission, particularly the ventral tegmental area-nucleus accumbens (VTA-NAcc) projection, underlies reward and aversion processing, and deficient DA function could underlie motivational impairments in psychiatric disorders. 6-hydroxydopamine (6-OHDA) injection is an established method for chron...

journal_title：Neuropharmacology

authors： Bergamini G,Sigrist H,Ferger B,Singewald N,Seifritz E,Pryce CR

更新日期：2016-10-01 00:00:00

abstract：:U50488H is a benzeneacetamide κ-opioid receptor (κ-OR) agonist analgesic, widely used for investigating the pharmacology of G protein-coupled κ-ORs. However, U50488H is also known to directly block various voltage-gated ion channels in a G protein-independent manner. We investigated the direct actions of U50488H on va...

journal_title：Neuropharmacology

authors： Berecki G,Motin L,Adams DJ

更新日期：2016-10-01 00:00:00

abstract：:Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels have a key role in the control of cellular excitability. HCN2, a subgroup of the HCN family channels, are heavily expressed in small dorsal root ganglia (DRG) neurons and their activation seems to be important in the determination of pain intensity. In...

journal_title：Neuropharmacology

authors： Resta F,Masi A,Sili M,Laurino A,Moroni F,Mannaioni G

更新日期：2016-09-01 00:00:00

abstract：:Akt is a serine/threonine kinase, which is dramatically reduced in the prefrontal cortex (PFC) of patients with schizophrenia, and a deficiency in Akt1 results in PFC function abnormalities. Although the importance of Akt in dopamine (DA) transmission is well established, how impaired Akt signaling affects the DA modu...

journal_title：Neuropharmacology

authors： Li YC,Yang SS,Gao WJ

更新日期：2016-09-01 00:00:00

abstract：:G-protein coupled dopamine and metabotropic glutamate receptors (mGlu) can modulate neurotransmission during Parkinson's disease (PD)-like neurodegeneration. PET imaging studies in a unilateral dopamine denervation model (6-OHDA) showed a significant inverse correlation of presynaptic mGlu4 and postsynaptic mGlu5 expr...

journal_title：Neuropharmacology

authors： Jenkins BG,Zhu A,Poutiainen P,Choi JK,Kil KE,Zhang Z,Kuruppu D,Aytan N,Dedeoglu A,Brownell AL

更新日期：2016-09-01 00:00:00

abstract：:Melanopsin-dependent phototransduction in intrinsically photosensitive retinal ganglion cells (ipRGCs) involves a Gq-coupled phospholipase C (PLC) signaling cascade. Acetylcholine, released in the mammalian retina by starburst amacrine cells, can also activate Gq-PLC pathways through certain muscarinic acetylcholine r...

journal_title：Neuropharmacology

authors： Sodhi P,Hartwick AT

更新日期：2016-09-01 00:00:00

abstract：:Studies with heterologous expression systems have shown that the α4β2 nicotinic acetylcholine receptor (nAChR) subtype can exist in two stoichiometries (with two [(α4)2(β2)3] or three [(α4)3(β2)2] copies of the α subunit in the receptor pentamer) which have different pharmacological and functional properties and are d...

journal_title：Neuropharmacology

authors： Fasoli F,Moretti M,Zoli M,Pistillo F,Crespi A,Clementi F,Mc Clure-Begley T,Marks MJ,Gotti C

更新日期：2016-09-01 00:00:00

abstract：:Long-term consumption of ethanol affects cortical areas that are important for learning and memory, cognition, and decision-making. Deficits in cortical function may contribute to alcohol-abuse disorders by impeding an individual's ability to control drinking. Previous studies from this laboratory show that acute etha...

journal_title：Neuropharmacology

authors： den Hartog C,Zamudio-Bulcock P,Nimitvilai S,Gilstrap M,Eaton B,Fedarovich H,Motts A,Woodward JJ

更新日期：2016-08-01 00:00:00